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Evidence Snapshot

Liver carboxylesterase

CHEMBL3383 SINGLE PROTEIN Sus scrofa
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:25Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3383
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Liver carboxylesterase as ChEMBL target CHEMBL3383, mapped to UniProt Q29550. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Liver carboxylesterase
SINGLE PROTEIN · Sus scrofa
As of 2026-09-13
ChEMBL target ID
CHEMBL3383
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q29550
Liver carboxylesterase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Liver carboxylesterase matters

As of 2026-09-13

Liver carboxylesterase is reviewed as Liver carboxylesterase (UniProt Q29550); the current evidence base includes 1 approved drug, 242 compounds, and 80 assays, with lead potency reaching pChEMBL 9.3.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 1 approved drug, 242 compounds, and 80 assays for this target. The dominant activity type is IC50. CHEMBL155514 is the current potency anchor at pChEMBL 9.3.

Use CHEMBL155514 as the tractability anchor when discussing potency (pChEMBL 9.3).

Activity source · ChEMBL 36 via Core Engine
1 approved pChEMBL 9.3
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Liver carboxylesterase matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q29550, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

242
Total Compounds
80
Total Assays
1
Approved Drugs
IC50: 206.0, KI: 19.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL155514
 9.3 IC50 —
No preferred name
CHEMBL270374
 8.9 IC50 —
No preferred name
CHEMBL440542
 8.7 IC50 —
No preferred name
CHEMBL89506
 8.6 IC50 —
No preferred name
CHEMBL269931
 8.5 IC50 —

Approved Drugs

Structure Compound First Approval
ISOFLUROPHATE
CHEMBL1025
 1957
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:25Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3383