Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL3536 Target Snapshot

ATP-dependent molecular chaperone HSP82 · SINGLE PROTEIN · Saccharomyces cerevisiae S288c

163Compounds
8Assays
0Approved Drugs
163.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P02829. Use UniProt P02829 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02829 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ATP-dependent molecular chaperone HSP82 as ChEMBL target CHEMBL3536, mapped to UniProt P02829. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ATP-dependent molecular chaperone HSP82
SINGLE PROTEIN · Saccharomyces cerevisiae S288c
As of 2026-09-14
ChEMBL target ID
CHEMBL3536
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P02829
ATP-dependent molecular chaperone HSP82
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ATP-dependent molecular chaperone HSP82 is the right protein anchor across sources, using UniProt P02829 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelATP-dependent molecular chaperone HSP82
UniProt AccessionP02829
Component TypeProtein
Sequence Length709 aa

ATP-dependent molecular chaperone HSP82

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ATP-dependent molecular chaperone HSP82, mapped to UniProt P02829. Sequence length is 709 aa.

Mapped IDP02829
Review nameATP-dependent molecular chaperone HSP82
OrganismSaccharomyces cerevisiae S288c
Clinical Profile

Clinical Phase Distribution

1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50161.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL414883 7.72 Kd 19.0 Preclinical
CHEMBL278315 5.92 Kd 1200.0 Clinical
CHEMBL361941 5.81 IC50 1550.0 Preclinical
CHEMBL191228 5.8 IC50 1600.0 Preclinical
CHEMBL364882 5.78 IC50 1650.0 Preclinical
CHEMBL278315 5.64 IC50 2300.0 Clinical
CHEMBL188495 5.62 IC50 2400.0 Preclinical
CHEMBL190249 5.62 IC50 2400.0 Preclinical
CHEMBL109480 5.18 IC50 6600.0 Clinical
CHEMBL399530 5.15 IC50 7100.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
7
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
13
Tested Compounds
2
Assay Types
Binding — 6 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 6 5 5.6
Functional — 2 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 13 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine