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Target Snapshot

CHEMBL3627592 Target Snapshot

Calcium/calmodulin-dependent protein kinase type 1B · SINGLE PROTEIN · Homo sapiens

185Compounds
81Assays
0Approved Drugs
18.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q6P2M8. Use UniProt Q6P2M8 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q6P2M8 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calcium/calmodulin-dependent protein kinase type 1B as ChEMBL target CHEMBL3627592, mapped to UniProt Q6P2M8. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calcium/calmodulin-dependent protein kinase type 1B
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3627592
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q6P2M8
Calcium/calmodulin-dependent protein kinase type 1B
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calcium/calmodulin-dependent protein kinase type 1B is the right protein anchor across sources, using UniProt Q6P2M8 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalcium/calmodulin-dependent protein kinase type 1B
UniProt AccessionQ6P2M8
Component TypeProtein
Sequence Length343 aa

Calcium/calmodulin-dependent protein kinase type 1B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Calcium/calmodulin-dependent protein kinase type 1B, mapped to UniProt Q6P2M8. Sequence length is 343 aa.

Mapped IDQ6P2M8
Review nameCalcium/calmodulin-dependent protein kinase type 1B
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5014.0
KD4.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4635883 8.52 IC50 3.0 Preclinical
CHEMBL388978 8.42 IC50 3.78 Preclinical
CHEMBL4640712 7.96 IC50 11.0 Preclinical
CHEMBL5093741 6.08 IC50 830.0 Preclinical
CHEMBL4088216 6.0 IC50 1000.0 Preclinical
CHEMBL4097778 6.0 IC50 1000.0 Preclinical
CHEMBL4549667 6.0 IC50 1000.0 Preclinical
CHEMBL4795714 5.52 IC50 3000.0 Preclinical
CHEMBL4848254 5.0 Kd 10000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
4
6.0
0
6.5
0
7.0
1
7.5
3
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

81
Total Assays
9
Tested Compounds
1
Assay Types
Binding — 81 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 65 8 7.1
assay format 14 1 5.0
cell-based format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine