Thioredoxin reductase · SINGLE PROTEIN · Escherichia coli (strain K12)
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As of 2026-09-14Protein identity stays anchored to UniProt P0A9P4. Use UniProt P0A9P4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P0A9P4 as the stable identity anchor, then attach disease evidence before program review.
Thioredoxin reductase
Review this target as Thioredoxin reductase, mapped to UniProt P0A9P4. Sequence length is 321 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin reductase as ChEMBL target CHEMBL3638339, mapped to UniProt P0A9P4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thioredoxin reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
| UniProt | P0A9P4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thioredoxin reductase |
| UniProt Accession | P0A9P4 |
| Component Type | Protein |
| Sequence Length | 321 aa |
Thioredoxin reductase
Review this target as Thioredoxin reductase, mapped to UniProt P0A9P4. Sequence length is 321 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2035464 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL2035461 | 7.4 | Ki | 40.0 | Preclinical |
| CHEMBL2035460 | 7.3 | Ki | 50.0 | Preclinical |
| CHEMBL3655713 | 6.6 | Ki | 250.0 | Preclinical |
| CHEMBL3655720 | 6.6 | Ki | 250.0 | Preclinical |
| CHEMBL51085 | 6.52 | Ki | 300.0 | Clinical |
| CHEMBL5395264 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL3655712 | 6.26 | Ki | 550.0 | Preclinical |
| CHEMBL5397149 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL5416840 | 6.16 | IC50 | 700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 23 | 5.8 |