Review anchor
Carnitine O-palmitoyltransferase 1, liver isoform
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Carnitine O-palmitoyltransferase 1, liver isoform
CHEMBL3858
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Carnitine O-palmitoyltransferase 1, liver isoform as ChEMBL target CHEMBL3858, mapped to UniProt P32198. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3858
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P32198
Carnitine O-palmitoyltransferase 1, liver isoform
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Carnitine O-palmitoyltransferase 1, liver isoform matters
Carnitine O-palmitoyltransferase 1, liver isoform is reviewed as Carnitine O-palmitoyltransferase 1, liver isoform (UniProt P32198); the current evidence base includes 1 approved drug, 527 compounds, and 27 assays, with lead potency reaching pChEMBL 8.5.
Protein context
Carnitine O-palmitoyltransferase 1, liver isoform
Carnitine O-palmitoyltransferase 1, liver isoform Sequence length is 773 aa.
Review this target as Carnitine O-palmitoyltransferase 1, liver isoform, mapped to UniProt P32198. Sequence length is 773 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P32198
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 527 compounds, and 27 assays for this target. The dominant activity type is IC50. CHEMBL3431816 is the current potency anchor at pChEMBL 8.5.
Use CHEMBL3431816 as the tractability anchor when discussing potency (pChEMBL 8.5).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 8.5
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Carnitine O-palmitoyltransferase 1, liver isoform matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P32198, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
527
Total Compounds
27
Total Assays
1
Approved Drugs
IC50: 516.0, KI: 5.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL3431816
|
8.5 | IC50 | — |
|
|
No preferred name
CHEMBL3431837
|
8.2 | IC50 | — |
|
|
No preferred name
CHEMBL3431815
|
8.1 | IC50 | — |
|
|
No preferred name
CHEMBL3431629
|
8.0 | IC50 | — |
|
|
No preferred name
CHEMBL3431830
|
8.0 | IC50 | — |
Source Header