Mitogen-activated protein kinase kinase kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Mitogen-activated protein kinase kinase kinase 1 shows clinical signal disease relevance led by psoriasis. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q13233. Start with psoriasis, then reuse UniProt Q13233 as the stable protein anchor across project notes and exports.
Start with psoriasis, then reuse UniProt Q13233 as the stable protein anchor across project notes and exports.
Mitogen-activated protein kinase kinase kinase 1 shows clinical signal disease relevance led by psoriasis. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with psoriasis because it currently carries clinical signal support. Linked drugs include E-6201. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMitogen-activated protein kinase kinase kinase 1
Review this target as Mitogen-activated protein kinase kinase kinase 1, mapped to UniProt Q13233. Sequence length is 1512 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 1 as ChEMBL target CHEMBL3956, mapped to UniProt Q13233. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Mitogen-activated protein kinase kinase kinase 1 is the right protein anchor across sources, using UniProt Q13233 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why psoriasis is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13233 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 1 |
| UniProt Accession | Q13233 |
| Component Type | Protein |
| Sequence Length | 1512 aa |
Mitogen-activated protein kinase kinase kinase 1
Review this target as Mitogen-activated protein kinase kinase kinase 1, mapped to UniProt Q13233. Sequence length is 1512 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Mitogen-activated protein kinase kinase kinase 1 shows clinical signal disease relevance led by psoriasis. 2 more disease programs remain visible in the same review block.
Start review with psoriasis because it currently carries clinical signal support. Linked drugs include E-6201. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL318804 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL2216826 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL1097700 | 7.34 | IC50 | 46.0 | Preclinical |
| CHEMBL3577124 | 7.01 | IC50 | 98.0 | Preclinical |
| CHEMBL607707 | 7.01 | Kd | 97.0 | Clinical |
| CHEMBL1908394 | 6.97 | Kd | 106.0 | Preclinical |
| CHEMBL288441 | 6.97 | Kd | 107.0 | Approved |
| CHEMBL253969 | 6.87 | Kd | 135.0 | Clinical |
| CHEMBL388978 | 6.46 | Kd | 350.0 | Preclinical |
| CHEMBL388978 | 6.41 | IC50 | 391.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 111 | 16 | 5.9 |
| assay format | 23 | 2 | 6.0 |
| cell-based format | 17 | 2 | 5.6 |
| subcellular format | 12 | 28 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 8.1 |