A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2) · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt G3V673. Use UniProt G3V673 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt G3V673 as the stable identity anchor, then attach disease evidence before program review.
A disintegrin and metalloproteinase with thrombospondin motifs 5
Review this target as A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2), mapped to UniProt G3V673. ChEMBL maps the protein component as A disintegrin and metalloproteinase with thrombospondin motifs 5. Sequence length is 927 aa.
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This review treats A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2) as ChEMBL target CHEMBL3988600, mapped to UniProt G3V673. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2) |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | G3V673 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Accession | G3V673 |
| Component Type | Protein |
| Sequence Length | 927 aa |
A disintegrin and metalloproteinase with thrombospondin motifs 5
Review this target as A disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 5 (Aggrecanase-2), mapped to UniProt G3V673. ChEMBL maps the protein component as A disintegrin and metalloproteinase with thrombospondin motifs 5. Sequence length is 927 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4066965 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL3980860 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL4072836 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL3972836 | 7.19 | IC50 | 64.0 | Preclinical |
| CHEMBL3955404 | 6.84 | IC50 | 146.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 1 | 5 | 7.5 |