Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q16816. Use UniProt Q16816 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16816 as the stable identity anchor, then attach disease evidence before program review.
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Review this target as Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, mapped to UniProt Q16816. Sequence length is 387 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform as ChEMBL target CHEMBL4004, mapped to UniProt Q16816. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q16816 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
| UniProt Accession | Q16816 |
| Component Type | Protein |
| Sequence Length | 387 aa |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Review this target as Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform, mapped to UniProt Q16816. Sequence length is 387 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL603469 | 9.41 | Kd | 0.39 | Clinical |
| CHEMBL388978 | 9.3 | Kd | 0.5 | Preclinical |
| CHEMBL4465866 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL388978 | 8.72 | IC50 | 1.92 | Preclinical |
| CHEMBL4576489 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL535 | 8.26 | Kd | 5.5 | Approved |
| CHEMBL4792981 | 7.92 | Kd | 12.0 | Preclinical |
| CHEMBL509032 | 7.77 | Kd | 17.0 | Preclinical |
| CHEMBL3815054 | 7.11 | IC50 | 78.0 | Preclinical |
| CHEMBL1721885 | 7.08 | Kd | 83.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 149 | 32 | 6.6 |
| assay format | 32 | 2 | 7.4 |
| cell-based format | 6 | 3 | 7.6 |