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Target Snapshot

CHEMBL4017 Target Snapshot

Sodium channel protein type 10 subunit alpha · SINGLE PROTEIN · Rattus norvegicus

491Compounds
26Assays
3Approved Drugs
509.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q62968. Use UniProt Q62968 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q62968 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium channel protein type 10 subunit alpha as ChEMBL target CHEMBL4017, mapped to UniProt Q62968. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium channel protein type 10 subunit alpha
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL4017
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q62968
Sodium channel protein type 10 subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium channel protein type 10 subunit alpha is the right protein anchor across sources, using UniProt Q62968 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium channel protein type 10 subunit alpha
UniProt AccessionQ62968
Component TypeProtein
Sequence Length1956 aa

Sodium channel protein type 10 subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium channel protein type 10 subunit alpha, mapped to UniProt Q62968. Sequence length is 1956 aa.

Mapped IDQ62968
Review nameSodium channel protein type 10 subunit alpha
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC50502.0
EC507.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5980244 9.1 IC50 0.8 Preclinical
CHEMBL5973279 9.05 IC50 0.9 Preclinical
CHEMBL3678273 9.0 IC50 1.0 Preclinical
CHEMBL3973953 9.0 IC50 1.0 Preclinical
CHEMBL5811186 9.0 IC50 1.0 Preclinical
CHEMBL5924371 9.0 IC50 1.0 Preclinical
CHEMBL5973592 9.0 IC50 1.0 Preclinical
CHEMBL3683097 8.7 IC50 2.0 Preclinical
CHEMBL3915190 8.7 IC50 2.0 Preclinical
CHEMBL5745992 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
30
5.5
55
6.0
57
6.5
112
7.0
132
7.5
60
8.0
8
8.5
8
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

26
Total Assays
486
Tested Compounds
1
Assay Types
Binding — 26 assays, 486 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 12 255 6.8
assay format 9 229 7.6
cell-based format 3 1 5.7
single protein format 2 1 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine