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Target Snapshot

CHEMBL4083 Target Snapshot

4-hydroxy-tetrahydrodipicolinate synthase · SINGLE PROTEIN · Escherichia coli K-12

31Compounds
22Assays
0Approved Drugs
31.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A6L2. Use UniProt P0A6L2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A6L2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 4-hydroxy-tetrahydrodipicolinate synthase as ChEMBL target CHEMBL4083, mapped to UniProt P0A6L2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
4-hydroxy-tetrahydrodipicolinate synthase
SINGLE PROTEIN · Escherichia coli K-12
As of 2026-09-14
ChEMBL target ID
CHEMBL4083
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A6L2
4-hydroxy-tetrahydrodipicolinate synthase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 4-hydroxy-tetrahydrodipicolinate synthase is the right protein anchor across sources, using UniProt P0A6L2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label4-hydroxy-tetrahydrodipicolinate synthase
UniProt AccessionP0A6L2
Component TypeProtein
Sequence Length292 aa

4-hydroxy-tetrahydrodipicolinate synthase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as 4-hydroxy-tetrahydrodipicolinate synthase, mapped to UniProt P0A6L2. Sequence length is 292 aa.

Mapped IDP0A6L2
Review name4-hydroxy-tetrahydrodipicolinate synthase
OrganismEscherichia coli K-12
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC5010.0
KI21.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1162545 4.8 Ki 16000.0 Preclinical
CHEMBL274323 4.05 Ki 90000.0 Clinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

22
Total Assays
26
Tested Compounds
1
Assay Types
Binding — 22 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 22 26 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine