General transcription and DNA repair factor IIH helicase subunit XPD · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P18074. Use UniProt P18074 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18074 as the stable identity anchor, then attach disease evidence before program review.
General transcription and DNA repair factor IIH helicase subunit XPD
Review this target as General transcription and DNA repair factor IIH helicase subunit XPD, mapped to UniProt P18074. Sequence length is 760 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats General transcription and DNA repair factor IIH helicase subunit XPD as ChEMBL target CHEMBL4105743, mapped to UniProt P18074. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | General transcription and DNA repair factor IIH helicase subunit XPD |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P18074 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | General transcription and DNA repair factor IIH helicase subunit XPD |
| UniProt Accession | P18074 |
| Component Type | Protein |
| Sequence Length | 760 aa |
General transcription and DNA repair factor IIH helicase subunit XPD
Review this target as General transcription and DNA repair factor IIH helicase subunit XPD, mapped to UniProt P18074. Sequence length is 760 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3128043 | 8.7 | Kd | 2.0 | Preclinical |
| CHEMBL1230607 | 8.0 | Kd | 10.0 | Preclinical |
| CHEMBL402548 | 6.87 | Kd | 134.0 | Clinical |
| CHEMBL3752910 | 6.75 | Kd | 179.7 | Preclinical |
| CHEMBL3544932 | 6.61 | Kd | 246.0 | Preclinical |
| CHEMBL1944698 | 6.5 | Kd | 319.0 | Clinical |
| CHEMBL564829 | 6.48 | Kd | 329.0 | Clinical |
| CHEMBL3545083 | 6.34 | Kd | 456.0 | Preclinical |
| CHEMBL2103840 | 6.25 | Kd | 560.0 | Clinical |
| CHEMBL428690 | 6.04 | Kd | 921.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 2 | 3 | 5.5 |
| subcellular format | 1 | 16 | 6.3 |