Use UniProt P63116 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4105976 Target Snapshot
Asc-type amino acid transporter 1 · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P63116. Use UniProt P63116 as the stable identity anchor, then attach disease evidence before program review.
Asc-type amino acid transporter 1
Review this target as Asc-type amino acid transporter 1, mapped to UniProt P63116. Sequence length is 530 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Asc-type amino acid transporter 1 as ChEMBL target CHEMBL4105976, mapped to UniProt P63116. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Asc-type amino acid transporter 1 is the right protein anchor across sources, using UniProt P63116 as the stable mapping.
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Open Review-ready CardBasic Information
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| Preferred Name | Asc-type amino acid transporter 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P63116 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Asc-type amino acid transporter 1 |
| UniProt Accession | P63116 |
| Component Type | Protein |
| Sequence Length | 530 aa |
Asc-type amino acid transporter 1
How to read this target
Review this target as Asc-type amino acid transporter 1, mapped to UniProt P63116. Sequence length is 530 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL285123 | 5.03 | IC50 | 9400.0 | Clinical |
| CHEMBL11298 | 5.02 | IC50 | 9600.0 | Clinical |
| CHEMBL63062 | 4.53 | IC50 | 29300.0 | Preclinical |
| CHEMBL4094153 | 4.21 | IC50 | 62000.0 | Preclinical |
| CHEMBL63130 | 4.07 | IC50 | 86000.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 1 assays, 12 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 1 | 12 | 4.6 |