Compound Detail

CHEMBL11298

SERINE

🧪 Phase III

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🧪 Phase III

N[C@@H](CO)C(=O)O

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL11298
Name	SERINE
Phase	Phase III
Structure Type	MOL
InChI Key	MTCFGRXMJLQNBG-REOHCLBHSA-N

Known Names

L-(-)-serine L-serine NSC-118365 Serina Serine

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

105.1

MW (Da)

-1.61

ALogP

HBA

HBD

83.5

PSA (Å²)

0.39

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Single Enantiomer

Flags

Natural Product

USAN Year

1979

Extended Properties

Molecular Formula	C3H7NO3
MW	105.09
Aromatic Rings	0
Heavy Atoms	7
NP-Likeness	1.41

Indications

Alzheimer Disease Amyotrophic Lateral Sclerosis Hereditary Sensory and Autonomic Neuropathies Mental Disorders Pancreatic Neoplasms Psychotic Disorders Schizophrenia Stress Disorders, Post-Traumatic

Activity Summary

IC50 8 meas. best 7.82

Ki 3 meas. best 4.3

EC50 2 meas.

Kd 1 meas.

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Acetylcholinesterase CHEMBL4078	IC50	7.82	7.82	15.0	1
Cholinesterase CHEMBL5763	IC50	7.8	7.8	16.0	1
Asc-type amino acid transporter 1 CHEMBL4105976	IC50	5.02	5.02	9600.0	1
Acetylcholinesterase CHEMBL220	IC50	4.42	4.42	38310.0	1
Glutathione hydrolase 1 proenzyme CHEMBL2943	Ki	4.3	4.3	50000.0	1
Amino acid transporter CHEMBL3562161	IC50	4.24	4.135	57900.0	2

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Acetylcholinesterase	IC50	=	15.0	nM	7.82	Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiochol...	25980913
Cholinesterase	IC50	=	16.0	nM	7.8	Inhibition of equine serum butyrylcholinesterase using butyrylthiocholineidioide...	25980913
Asc-type amino acid transporter 1	IC50	=	9600.0	nM	5.02	Inhibition of asc-1 mediated [3H]-D-serine uptake in P2 fraction of rat forebrai...	-
Acetylcholinesterase	IC50	=	38310.0	nM	4.42	Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodi...	37856864
Glutathione hydrolase 1 proenzyme	Ki	=	50000.0	nM	4.3	Inhibition of Rattus norvegicus Wistar (rat) rat Gamma-glutamyltranspeptidase us...	-
Amino acid transporter	IC50	=	57900.0	nM	4.24	Inhibition of ASCT2 mediated [3H]-D-serine uptake in rat hippocampal astrocytes	-
Amino acid transporter	IC50	=	94000.0	nM	4.03	Inhibition of ASCT2 mediated [3H]-L-serine uptake in rat hippocampal astrocytes ...	-

Literature References

PubMed	DOI	Target Context	# Activities
37468498	10.1038/s41467-023-40064-9	Thromboxane A2 receptor	2
37468498	10.1038/s41467-023-40064-9	Prostaglandin G/H synthase 1	2
37468498	10.1038/s41467-023-40064-9	Alpha-1A adrenergic receptor	2
21955456	10.1016/j.bmc.2011.08.058	Proton-coupled amino acid transporter 1	2
37468498	10.1038/s41467-023-40064-9	Muscarinic acetylcholine receptor M1	2
-	10.1007/s00044-004-0112-9	Gamma-glutamyltranspeptidase	1
37468498	10.1038/s41467-023-40064-9	Estrogen receptor	1
37468498	10.1038/s41467-023-40064-9	Sodium-dependent dopamine transporter	1
37468498	10.1038/s41467-023-40064-9	D(1A) dopamine receptor	1
34726055	10.1021/acs.jmedchem.1c00981	Pyruvate kinase PKM	1
25980913	10.1016/j.bmcl.2015.04.086	Acetylcholinesterase	1
25980913	10.1016/j.bmcl.2015.04.086	Cholinesterase	1
-	10.1007/s00044-004-0112-9	Glutathione hydrolase 1 proenzyme	1
9871712	10.1016/s0960-894x(98)00164-4	Unchecked	1
11278508	10.1074/jbc.m009462200	Monocarboxylate transporter 10	1
19060912	10.1038/nchembio.132	General amino-acid permease GAP1	1
19791805	10.1021/jm900775q	Unchecked	1
17230192	10.1038/nature05455	Unchecked	1
37856864	10.1021/acs.jnatprod.3c00465	Acetylcholinesterase	1
3656360	10.1021/jm00393a031	No relevant target	1

Data from ChEMBL 36 via Core Engine