MDM2-MDMX · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q00987. Use UniProt Q00987 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q00987 as the stable identity anchor, then attach disease evidence before program review.
E3 ubiquitin-protein ligase Mdm2
Review this target as MDM2-MDMX, mapped to UniProt Q00987. ChEMBL maps the protein component as E3 ubiquitin-protein ligase Mdm2. Sequence length is 491 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats MDM2-MDMX as ChEMBL target CHEMBL4106123, mapped to UniProt Q00987. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | MDM2-MDMX |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | Q00987 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | E3 ubiquitin-protein ligase Mdm2 |
| UniProt Accession | Q00987 |
| Component Type | Protein |
| Sequence Length | 491 aa |
E3 ubiquitin-protein ligase Mdm2
Review this target as MDM2-MDMX, mapped to UniProt Q00987. ChEMBL maps the protein component as E3 ubiquitin-protein ligase Mdm2. Sequence length is 491 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1352521 | 8.43 | IC50 | 3.74 | Preclinical |
| CHEMBL1579258 | 5.88 | IC50 | 1330.0 | Preclinical |
| CHEMBL3189193 | 5.57 | IC50 | 2680.0 | Preclinical |
| CHEMBL1370413 | 5.54 | IC50 | 2850.0 | Preclinical |
| CHEMBL1547940 | 5.48 | IC50 | 3280.0 | Preclinical |
| CHEMBL48310 | 5.45 | IC50 | 3580.0 | Preclinical |
| CHEMBL1603457 | 5.43 | IC50 | 3680.0 | Preclinical |
| CHEMBL270605 | 5.43 | IC50 | 3730.0 | Preclinical |
| CHEMBL1522344 | 5.41 | IC50 | 3910.0 | Preclinical |
| CHEMBL532504 | 5.41 | IC50 | 3920.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 19 | 5.5 |