Compound Detail
CHEMBL1352521
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Basic Information
| ChEMBL ID | CHEMBL1352521 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PQLXBUALUZFSAJ-UHFFFAOYSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
3.93
ALogP
5
HBA
1
HBD
48.0
PSA (Ų)
0.45
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.45
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3.53 | nM | 8.45 | PUBCHEM_BIOASSAY: Dose Response confirmation of Inhibitors of Mdm2/MdmX interact... | - |
| MDM2-MDMX | IC50 | = | 3.74 | nM | 8.43 | PUBCHEM_BIOASSAY: Dose Response confirmation of Inhibitors of Mdm2/MdmX interact... | - |
| Unchecked | IC50 | = | 550.0 | nM | 6.26 | PUBCHEM_BIOASSAY: Dose Response selectivity of uHTS chemical inhibitors of T-cel... | - |
| Unchecked | IC50 | = | 2375.0 | nM | 5.62 | PUBCHEM_BIOASSAY: Dose Response confirmation of Inhibitors of Mdm2/MdmX interact... | - |
| Unchecked | IC50 | = | 4590.0 | nM | 5.34 | PUBCHEM_BIOASSAY: Dose response counterscreen of uHTS chemical inhibitors of T-c... | - |
| Unchecked | IC50 | = | 13000.0 | nM | 4.89 | PUBCHEM_BIOASSAY: Dose response confirmation of uHTS chemical inhibitors of T-ce... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22088955 | 10.1016/j.ejmech.2011.10.035 | Collagenase 3 | 1 |
Data from ChEMBL 36 via Core Engine