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Target Snapshot

CHEMBL4131 Target Snapshot

Sodium/potassium-transporting ATPase subunit alpha-1 · SINGLE PROTEIN · Sus scrofa

13Compounds
5Assays
0Approved Drugs
10.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P05024. Use UniProt P05024 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P05024 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium/potassium-transporting ATPase subunit alpha-1 as ChEMBL target CHEMBL4131, mapped to UniProt P05024. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium/potassium-transporting ATPase subunit alpha-1
SINGLE PROTEIN · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL4131
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P05024
Sodium/potassium-transporting ATPase subunit alpha-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium/potassium-transporting ATPase subunit alpha-1 is the right protein anchor across sources, using UniProt P05024 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium/potassium-transporting ATPase subunit alpha-1
UniProt AccessionP05024
Component TypeProtein
Sequence Length1021 aa

Sodium/potassium-transporting ATPase subunit alpha-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium/potassium-transporting ATPase subunit alpha-1, mapped to UniProt P05024. Sequence length is 1021 aa.

Mapped IDP05024
Review nameSodium/potassium-transporting ATPase subunit alpha-1
OrganismSus scrofa
Assay Mix

Activity Type Distribution

IC5010.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL175806 7.17 IC50 68.0 Preclinical
CHEMBL178993 7.12 IC50 75.0 Preclinical
CHEMBL369515 5.72 IC50 1888.0 Preclinical
CHEMBL366906 5.39 IC50 4076.0 Preclinical
CHEMBL175981 4.92 IC50 12105.0 Preclinical
CHEMBL427124 4.3 IC50 50000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
0
6.0
0
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 5 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 6 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine