Review anchor
Protein tyrosine phosphatase type IVA 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Protein tyrosine phosphatase type IVA 3
CHEMBL4162
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein tyrosine phosphatase type IVA 3 as ChEMBL target CHEMBL4162, mapped to UniProt O75365. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4162
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O75365
Protein tyrosine phosphatase type IVA 3
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Protein tyrosine phosphatase type IVA 3 matters
Protein tyrosine phosphatase type IVA 3 is reviewed as Protein tyrosine phosphatase type IVA 3 (UniProt O75365); the current evidence base includes 1 approved drug, 109 compounds, and 58 assays, with lead potency reaching pChEMBL 7.8.
Protein context
Protein tyrosine phosphatase type IVA 3
Protein tyrosine phosphatase type IVA 3 Sequence length is 173 aa.
Review this target as Protein tyrosine phosphatase type IVA 3, mapped to UniProt O75365. Sequence length is 173 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt O75365
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 109 compounds, and 58 assays for this target. The dominant activity type is IC50. CHEMBL4445621 is the current potency anchor at pChEMBL 7.8.
Use CHEMBL4445621 as the tractability anchor when discussing potency (pChEMBL 7.8).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 7.8
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Protein tyrosine phosphatase type IVA 3 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt O75365, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
109
Total Compounds
58
Total Assays
1
Approved Drugs
IC50: 101.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL4445621
|
7.8 | IC50 | — |
|
|
No preferred name
CHEMBL4471843
|
7.5 | IC50 | — |
|
|
No preferred name
CHEMBL4862721
|
7.0 | IC50 | — |
|
|
No preferred name
CHEMBL3393171
|
6.9 | IC50 | — |
|
|
No preferred name
CHEMBL4862502
|
6.7 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PENTAMIDINE
CHEMBL55
|
1984 |
Source Header