Potassium voltage-gated channel subfamily A member 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P22459. Use UniProt P22459 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22459 as the stable identity anchor, then attach disease evidence before program review.
Potassium voltage-gated channel subfamily A member 4
Review this target as Potassium voltage-gated channel subfamily A member 4, mapped to UniProt P22459. Sequence length is 653 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Potassium voltage-gated channel subfamily A member 4 as ChEMBL target CHEMBL4205, mapped to UniProt P22459. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Potassium voltage-gated channel subfamily A member 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P22459 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Potassium voltage-gated channel subfamily A member 4 |
| UniProt Accession | P22459 |
| Component Type | Protein |
| Sequence Length | 653 aa |
Potassium voltage-gated channel subfamily A member 4
Review this target as Potassium voltage-gated channel subfamily A member 4, mapped to UniProt P22459. Sequence length is 653 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL444449 | 7.12 | EC50 | 75.0 | Preclinical |
| CHEMBL444449 | 6.77 | IC50 | 170.0 | Preclinical |
| CHEMBL3906400 | 6.3 | EC50 | 500.0 | Preclinical |
| CHEMBL259345 | 5.89 | EC50 | 1300.0 | Preclinical |
| CHEMBL4207745 | 5.82 | IC50 | 1500.0 | Preclinical |
| CHEMBL397591 | 5.68 | IC50 | 2100.0 | Preclinical |
| CHEMBL408488 | 5.64 | EC50 | 2300.0 | Preclinical |
| CHEMBL426482 | 5.37 | EC50 | 4300.0 | Preclinical |
| CHEMBL382154 | 5.32 | EC50 | 4800.0 | Preclinical |
| CHEMBL3621636 | 5.28 | IC50 | 5300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 12 | 5.4 |
| single protein format | 2 | 2 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 1 | 4.7 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 2 | 5.3 |