Compound Detail
CHEMBL259345
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Basic Information
| ChEMBL ID | CHEMBL259345 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MTAMEGDGUHKHET-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
288.1
MW (Da)
2.10
ALogP
4
HBA
0
HBD
61.6
PSA (Ų)
0.36
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 4 CHEMBL4205 | EC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Potassium voltage-gated channel subfamily A member 1 CHEMBL2309 | EC50 | 5.22 | 5.22 | 6000.0 | 1 |
| Voltage-gated potassium channel subfamily A member 1/beta-1 CHEMBL3988636 | EC50 | 5.05 | 5.05 | 8900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 4 | EC50 | = | 1300.0 | nM | 5.89 | Inhibition of Kv1.4 channel inactivation expressed in xenopus oocytes by voltage... | 18226531 |
| Potassium voltage-gated channel subfamily A member 1 | EC50 | = | 6000.0 | nM | 5.22 | Inhibition of Kvbeta-1-mediated inactivation of Kv1.1 channel expressed in xenop... | 18226531 |
| Voltage-gated potassium channel subfamily A member 1/beta-1 | EC50 | = | 8900.0 | nM | 5.05 | Inhibition of Kv1.1/Kvbeta1 N terminal chimera channel inactivation expressed in... | 18226531 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18226531 | 10.1016/j.bmc.2007.12.031 | Potassium voltage-gated channel subfamily A member 1 | 2 |
| 18226531 | 10.1016/j.bmc.2007.12.031 | Voltage-gated potassium channel subfamily A member 1/beta-1 | 1 |
| 18226531 | 10.1016/j.bmc.2007.12.031 | Potassium voltage-gated channel subfamily A member 4 | 1 |
| 18226531 | 10.1016/j.bmc.2007.12.031 | A-type voltage-gated potassium channel KCND2 | 1 |
Data from ChEMBL 36 via Core Engine