Assay Detail
Binding
CHEMBL939982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kvbeta-1-mediated inactivation of Kv1.1 channel expressed in xenopus oocytes by voltage clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 1 (CHEMBL2309) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.30 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408488 | — | — | 1 | 5.37 |
| CHEMBL259345 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408488 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL259345 | — | EC50 | = | 6000.0 | nM | 5.22 |