Assay Detail
Binding
CHEMBL939983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kv1.1/Kvbeta1 N terminal chimera channel inactivation expressed in xenopus oocytes by voltage clamp assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel subfamily A member 1/beta-1 (CHEMBL3988636) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 3 | - | - |
| EC50 | 2 | 4.92 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259345 | — | — | 1 | 5.05 |
| CHEMBL408488 | — | — | 1 | 4.78 |
| CHEMBL258937 | — | — | 1 | - |
| CHEMBL258938 | — | — | 1 | - |
| CHEMBL259564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259345 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL408488 | — | EC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL258937 | — | Activity | - | — | - | |
| CHEMBL258938 | — | Activity | - | — | - | |
| CHEMBL259564 | — | Activity | - | — | - |