Assay Detail
Binding
CHEMBL939978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Kv1.4 channel inactivation expressed in xenopus oocytes by voltage clamp assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Potassium voltage-gated channel subfamily A member 4 (CHEMBL4205) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.77 | 5.89 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259345 | — | — | 1 | 5.89 |
| CHEMBL408488 | — | — | 1 | 5.64 |
| CHEMBL259564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259345 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL408488 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL259564 | — | Activity | - | — | - |