Tyrosine-protein kinase Tec · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P42680. Use UniProt P42680 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P42680 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase Tec
Review this target as Tyrosine-protein kinase Tec, mapped to UniProt P42680. Sequence length is 631 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein kinase Tec as ChEMBL target CHEMBL4246, mapped to UniProt P42680. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein kinase Tec |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P42680 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase Tec |
| UniProt Accession | P42680 |
| Component Type | Protein |
| Sequence Length | 631 aa |
Tyrosine-protein kinase Tec
Review this target as Tyrosine-protein kinase Tec, mapped to UniProt P42680. Sequence length is 631 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5827965 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL4206765 | 10.05 | IC50 | 0.09 | Preclinical |
| CHEMBL4217959 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4214683 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL5780981 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL5948251 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL5787507 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL4219011 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL5872571 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL5785815 | 9.72 | IC50 | 0.19 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 220 | 292 | 7.7 |
| assay format | 42 | 19 | 7.1 |
| cell-based format | 12 | 11 | 7.7 |
| subcellular format | 12 | 20 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 9 | 8.4 |
| assay format | 4 | 2 | 7.0 |
| cell-based format | 2 | 2 | 7.0 |