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Evidence Snapshot

Tyrosine-protein kinase Tec

CHEMBL4246 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4246
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tyrosine-protein kinase Tec as ChEMBL target CHEMBL4246, mapped to UniProt P42680. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tyrosine-protein kinase Tec
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4246
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P42680
Tyrosine-protein kinase Tec
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Tyrosine-protein kinase Tec matters

As of 2026-09-14

Tyrosine-protein kinase Tec is reviewed as Tyrosine-protein kinase Tec (UniProt P42680); the current evidence base includes 15 approved drugs, 1366 compounds, and 297 assays, with lead potency reaching pChEMBL 10.1.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 15 approved drugs, 1366 compounds, and 297 assays for this target. The dominant activity type is KD. CHEMBL5827965 is the current potency anchor at pChEMBL 10.1.

Use CHEMBL5827965 as the tractability anchor when discussing potency (pChEMBL 10.1).

Activity source · ChEMBL 36 via Core Engine
15 approved pChEMBL 10.1
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Tyrosine-protein kinase Tec matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P42680, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1366
Total Compounds
297
Total Assays
15
Approved Drugs
IC50: 366.0, KI: 1.0, EC50: 5.0, KD: 394.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5827965
 10.1 IC50 —
No preferred name
CHEMBL4206765
 10.1 IC50 —
No preferred name
CHEMBL4217959
 10.0 IC50 —
No preferred name
CHEMBL4214683
 10.0 IC50 —
No preferred name
CHEMBL5780981
 9.9 IC50 —

Approved Drugs

Structure Compound First Approval
RITLECITINIB
CHEMBL4085457
 2023
TIRABRUTINIB
CHEMBL4071161
 2020
ZANUBRUTINIB
CHEMBL3936761
 2019
ACALABRUTINIB
CHEMBL3707348
 2017
OSIMERTINIB
CHEMBL3353410
 2015
IBRUTINIB
CHEMBL1873475
 2013
BOSUTINIB
CHEMBL288441
 2012
DASATINIB
CHEMBL5416410
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:34Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4246