Bifunctional dihydrofolate reductase-thymidylate synthase · SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)
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As of 2026-09-13Protein identity stays anchored to UniProt Q8I1R6. Use UniProt Q8I1R6 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8I1R6 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q8I1R6. Sequence length is 608 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional dihydrofolate reductase-thymidylate synthase as ChEMBL target CHEMBL4296323, mapped to UniProt Q8I1R6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Bifunctional dihydrofolate reductase-thymidylate synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
| UniProt | Q8I1R6 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional dihydrofolate reductase-thymidylate synthase |
| UniProt Accession | Q8I1R6 |
| Component Type | Protein |
| Sequence Length | 608 aa |
Bifunctional dihydrofolate reductase-thymidylate synthase
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q8I1R6. Sequence length is 608 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL36 | 9.07 | Ki | 0.85 | Approved |
| CHEMBL129788 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL129788 | 6.53 | Ki | 292.3 | Preclinical |
| CHEMBL36 | 5.61 | IC50 | 2480.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 7.1 |