Review anchor
Bifunctional dihydrofolate reductase-thymidylate synthase
SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)
As of 2026-09-13
Evidence Snapshot
Bifunctional dihydrofolate reductase-thymidylate synthase
CHEMBL4296323
SINGLE PROTEIN
Plasmodium falciparum (isolate 3D7)
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional dihydrofolate reductase-thymidylate synthase as ChEMBL target CHEMBL4296323, mapped to UniProt Q8I1R6. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4296323
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q8I1R6
Bifunctional dihydrofolate reductase-thymidylate synthase
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Bifunctional dihydrofolate reductase-thymidylate synthase matters
Bifunctional dihydrofolate reductase-thymidylate synthase is reviewed as Bifunctional dihydrofolate reductase-thymidylate synthase (UniProt Q8I1R6); the current evidence base includes 2 approved drugs, 2 compounds, and 2 assays, with lead potency reaching pChEMBL 9.1.
Protein context
Bifunctional dihydrofolate reductase-thymidylate synthase
Bifunctional dihydrofolate reductase-thymidylate synthase Sequence length is 608 aa.
Review this target as Bifunctional dihydrofolate reductase-thymidylate synthase, mapped to UniProt Q8I1R6. Sequence length is 608 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q8I1R6
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 2 approved drugs, 2 compounds, and 2 assays for this target. The dominant activity type is IC50. CHEMBL36 is the current potency anchor at pChEMBL 9.1.
Use CHEMBL36 as the tractability anchor when discussing potency (pChEMBL 9.1).
Activity source · ChEMBL 36 via Core Engine
2 approved
pChEMBL 9.1
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Bifunctional dihydrofolate reductase-thymidylate synthase matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q8I1R6, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
2
Total Compounds
2
Total Assays
2
Approved Drugs
IC50: 2.0, KI: 2.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL36
|
9.1 | Ki | Approved |
|
|
No preferred name
CHEMBL129788
|
7.0 | IC50 | — |
|
|
No preferred name
CHEMBL129788
|
6.5 | Ki | — |
|
|
No preferred name
CHEMBL36
|
5.6 | IC50 | Approved |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
PYRIMETHAMINE
CHEMBL36
|
1953 |
Source Header