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Target Snapshot

CHEMBL4296470 Target Snapshot

MHCC97H · CELL-LINE · Homo sapiens

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137Compounds
114Assays
3Approved Drugs
146.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MHCC97H as ChEMBL target CHEMBL4296470. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MHCC97H
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4296470
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MHCC97H still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMHCC97H
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMHCC97H
UniProt AccessionN/A

MHCC97H

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MHCC97H.

Review nameMHCC97H
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50146.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL65 9.49 IC50 0.32 Preclinical
CHEMBL5575349 8.99 IC50 1.03 Preclinical
CHEMBL3402762 8.93 IC50 1.18 Approved
CHEMBL3334567 8.61 IC50 2.46 Clinical
CHEMBL5575924 8.6 IC50 2.49 Preclinical
CHEMBL2105717 8.58 IC50 2.62 Approved
CHEMBL5558415 8.58 IC50 2.62 Preclinical
CHEMBL5596699 8.37 IC50 4.3 Preclinical
CHEMBL5562974 8.31 IC50 4.84 Preclinical
CHEMBL5570796 8.31 IC50 4.94 Preclinical
Distribution

pChEMBL Value Distribution

12
5.0
0
5.5
8
6.0
18
6.5
10
7.0
16
7.5
12
8.0
6
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TEPOTINIB
CHEMBL3402762
Approved 2020
Properties Compare Identifier
CABOZANTINIB
CHEMBL2105717
Approved 2012
Properties Compare Identifier
Assay Landscape

Assay Landscape

114
Total Assays
110
Tested Compounds
1
Assay Types
Functional — 114 assays, 110 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 97 110 6.4
organism-based format 17 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine