Compound Detail
CHEMBL5562974
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Basic Information
| ChEMBL ID | CHEMBL5562974 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNMVLJFZQPPKBG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
420.5
MW (Da)
3.84
ALogP
6
HBA
0
HBD
76.3
PSA (Ų)
0.44
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MHCC97H CHEMBL4296470 | IC50 | 8.31 | 8.31 | 4.8 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MHCC97H | IC50 | = | 4.84 | nM | 8.31 | Antiproliferative activity against human MHCC97H cells assessed as reduction in ... | 38086189 |
| Hepatocyte growth factor receptor | IC50 | = | 10.01 | nM | 8.0 | Inhibition of c-Met (unknown origin) preincubated for 10 mins followed by substr... | 38086189 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38086189 | 10.1016/j.ejmech.2023.116025 | Hepatocyte growth factor receptor | 1 |
| 38086189 | 10.1016/j.ejmech.2023.116025 | MHCC97H | 1 |
Data from ChEMBL 36 via Core Engine