Assay Detail
Binding
CHEMBL5528873
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Inhibition of c-Met (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 50 mins by fluorescence based microtiter-plate reader analysis
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.90 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575349 | — | — | 1 | 9.35 |
| CHEMBL5575781 | — | — | 1 | 8.94 |
| CHEMBL5592986 | — | — | 1 | 8.88 |
| CHEMBL5567451 | — | — | 1 | 8.84 |
| CHEMBL5591802 | — | — | 1 | 8.65 |
| CHEMBL5571790 | — | — | 1 | 8.64 |
| CHEMBL5573791 | — | — | 1 | 8.61 |
| CHEMBL5569712 | — | — | 1 | 8.57 |
| CHEMBL5570382 | — | — | 1 | 8.47 |
| CHEMBL5570380 | — | — | 1 | 8.43 |
| CHEMBL5575924 | — | — | 1 | 8.37 |
| CHEMBL3334567 | SAVOLITINIB | 3.0 | 1 | 8.32 |
| CHEMBL5570796 | — | — | 1 | 8.31 |
| CHEMBL5590979 | — | — | 1 | 8.25 |
| CHEMBL5565165 | — | — | 1 | 8.24 |
| CHEMBL5569225 | — | — | 1 | 8.22 |
| CHEMBL5569113 | — | — | 1 | 8.20 |
| CHEMBL5566002 | — | — | 1 | 8.20 |
| CHEMBL5569721 | — | — | 1 | 8.15 |
| CHEMBL5571802 | — | — | 1 | 8.12 |
| CHEMBL5591822 | — | — | 1 | 8.07 |
| CHEMBL5564835 | — | — | 1 | 8.06 |
| CHEMBL5557397 | — | — | 1 | 8.05 |
| CHEMBL5565374 | — | — | 1 | 8.04 |
| CHEMBL5562974 | — | — | 1 | 8.00 |
| CHEMBL5573884 | — | — | 1 | 8.00 |
| CHEMBL5556933 | — | — | 1 | 7.97 |
| CHEMBL5564751 | — | — | 1 | 7.95 |
| CHEMBL5595001 | — | — | 1 | 7.94 |
| CHEMBL5570825 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575349 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5575781 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL5592986 | — | IC50 | = | 1.32 | nM | 8.88 |
| CHEMBL5567451 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL5591802 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL5571790 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5573791 | — | IC50 | = | 2.46 | nM | 8.61 |
| CHEMBL5569712 | — | IC50 | = | 2.69 | nM | 8.57 |
| CHEMBL5570382 | — | IC50 | = | 3.35 | nM | 8.47 |
| CHEMBL5570380 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL5575924 | — | IC50 | = | 4.29 | nM | 8.37 |
| CHEMBL3334567 | SAVOLITINIB | IC50 | = | 4.77 | nM | 8.32 |
| CHEMBL5570796 | — | IC50 | = | 4.91 | nM | 8.31 |
| CHEMBL5590979 | — | IC50 | = | 5.68 | nM | 8.25 |
| CHEMBL5565165 | — | IC50 | = | 5.71 | nM | 8.24 |
| CHEMBL5569225 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5569113 | — | IC50 | = | 6.25 | nM | 8.20 |
| CHEMBL5566002 | — | IC50 | = | 6.29 | nM | 8.20 |
| CHEMBL5569721 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5571802 | — | IC50 | = | 7.64 | nM | 8.12 |
| CHEMBL5591822 | — | IC50 | = | 8.57 | nM | 8.07 |
| CHEMBL5564835 | — | IC50 | = | 8.61 | nM | 8.06 |
| CHEMBL5557397 | — | IC50 | = | 8.88 | nM | 8.05 |
| CHEMBL5565374 | — | IC50 | = | 9.15 | nM | 8.04 |
| CHEMBL5562974 | — | IC50 | = | 10.01 | nM | 8.00 |
| CHEMBL5573884 | — | IC50 | = | 10.04 | nM | 8.00 |
| CHEMBL5556933 | — | IC50 | = | 10.69 | nM | 7.97 |
| CHEMBL5564751 | — | IC50 | = | 11.19 | nM | 7.95 |
| CHEMBL5595001 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5570825 | — | IC50 | = | 11.96 | nM | 7.92 |
| CHEMBL5573922 | — | IC50 | = | 19.85 | nM | 7.70 |
| CHEMBL5565360 | — | IC50 | = | 25.05 | nM | 7.60 |
| CHEMBL5565055 | — | IC50 | = | 26.22 | nM | 7.58 |
| CHEMBL5569641 | — | IC50 | = | 26.19 | nM | 7.58 |
| CHEMBL5595583 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5565032 | — | IC50 | = | 71.02 | nM | 7.15 |
| CHEMBL5566607 | — | IC50 | = | 71.83 | nM | 7.14 |
| CHEMBL5570518 | — | IC50 | = | 99.9 | nM | 7.00 |
| CHEMBL5557718 | — | IC50 | = | 110.6 | nM | 6.96 |
| CHEMBL5564888 | — | IC50 | = | 113.4 | nM | 6.95 |
| CHEMBL5571069 | — | IC50 | = | 114.2 | nM | 6.94 |
| CHEMBL5573123 | — | IC50 | = | 737.1 | nM | 6.13 |
| CHEMBL5572507 | — | IC50 | = | 1138.0 | nM | 5.94 |
| CHEMBL5589820 | — | IC50 | = | 3203.0 | nM | 5.49 |
| CHEMBL5563141 | — | IC50 | > | 10000.0 | nM | - |