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Target Snapshot

CHEMBL4296499 Target Snapshot

TC-32 · CELL-LINE · Homo sapiens

73Compounds
38Assays
2Approved Drugs
42.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats TC-32 as ChEMBL target CHEMBL4296499. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
TC-32
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296499
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether TC-32 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTC-32
UniProt AccessionN/A

TC-32

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as TC-32.

Review nameTC-32
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5042.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL575448 8.1 IC50 8.0 Clinical
CHEMBL1750 6.89 IC50 130.0 Approved
CHEMBL5403230 6.27 IC50 540.0 Preclinical
CHEMBL4164729 6.14 IC50 720.0 Preclinical
CHEMBL5394819 5.82 IC50 1530.0 Preclinical
CHEMBL1650595 5.7 IC50 2000.0 Preclinical
CHEMBL1619 5.54 IC50 2920.0 Approved
CHEMBL5396703 5.47 IC50 3370.0 Preclinical
CHEMBL5419608 5.34 IC50 4570.0 Preclinical
CHEMBL3600873 5.25 IC50 5600.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
3
5.5
2
6.0
1
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CLOFARABINE
CHEMBL1750
Approved 2004
Assay Landscape

Assay Landscape

38
Total Assays
18
Tested Compounds
3
Assay Types
Functional — 32 assays, 18 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 32 18 5.3
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine