Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4296516 Target Snapshot

Calvarial osteoblast · CELL-LINE

Back to Search Search this target Browse approvals Evidence Card
170Compounds
199Assays
1Approved Drugs
19.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calvarial osteoblast as ChEMBL target CHEMBL4296516. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calvarial osteoblast
CELL-LINE
As of 2026-09-15
ChEMBL target ID
CHEMBL4296516
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calvarial osteoblast still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCalvarial osteoblast
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalvarial osteoblast
UniProt AccessionN/A

Calvarial osteoblast

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Calvarial osteoblast.

Review nameCalvarial osteoblast
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

EC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4208523 10.0 EC50 0.1 Preclinical
CHEMBL1829658 8.99 EC50 1.015 Preclinical
CHEMBL3289673 8.19 EC50 6.46 Preclinical
CHEMBL4276975 8.12 EC50 7.586 Preclinical
CHEMBL4205746 8.0 EC50 10.0 Preclinical
CHEMBL4208863 8.0 EC50 10.0 Preclinical
CHEMBL4205618 7.5 EC50 31.4 Preclinical
CHEMBL2313143 6.0 EC50 1010.0 Preclinical
CHEMBL2311555 5.94 EC50 1140.0 Preclinical
CHEMBL2313436 5.93 EC50 1170.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
5
5.5
1
6.0
0
6.5
0
7.0
1
7.5
4
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

199
Total Assays
19
Tested Compounds
3
Assay Types
Functional — 186 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 186 19 6.6
ADME — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 0 —
Toxicity — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine