Heat shock protein HSP 90-beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P08238. Use UniProt P08238 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08238 as the stable identity anchor, then attach disease evidence before program review.
Heat shock protein HSP 90-beta
Review this target as Heat shock protein HSP 90-beta, mapped to UniProt P08238. Sequence length is 724 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Heat shock protein HSP 90-beta as ChEMBL target CHEMBL4303, mapped to UniProt P08238. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Heat shock protein HSP 90-beta is the right protein anchor across sources, using UniProt P08238 as the stable mapping.
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| Preferred Name | Heat shock protein HSP 90-beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08238 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Heat shock protein HSP 90-beta |
| UniProt Accession | P08238 |
| Component Type | Protein |
| Sequence Length | 724 aa |
Heat shock protein HSP 90-beta
Review this target as Heat shock protein HSP 90-beta, mapped to UniProt P08238. Sequence length is 724 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL252164 | 10.19 | Ki | 0.064 | Clinical |
| CHEMBL1917878 | 9.46 | Kd | 0.35 | Preclinical |
| CHEMBL3752910 | 9.26 | Kd | 0.546 | Preclinical |
| CHEMBL3309997 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL560895 | 8.96 | Ki | 1.1 | Preclinical |
| CHEMBL2419342 | 8.8 | Kd | 1.6 | Preclinical |
| CHEMBL252164 | 8.77 | Kd | 1.7 | Clinical |
| CHEMBL467399 | 8.77 | Kd | 1.7 | Clinical |
| CHEMBL467399 | 8.77 | Ki | 1.7 | Clinical |
| CHEMBL5574581 | 8.7 | Kd | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 317 | 95 | 6.7 |
| single protein format | 125 | 575 | 6.4 |
| assay format | 26 | 59 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 9 | 6.6 |
| tissue-based format | 2 | 3 | 5.1 |
| assay format | 1 | 3 | 5.5 |