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Evidence Snapshot

Heat shock protein HSP 90-beta

CHEMBL4303 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:45Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4303
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Heat shock protein HSP 90-beta as ChEMBL target CHEMBL4303, mapped to UniProt P08238. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Heat shock protein HSP 90-beta
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4303
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08238
Heat shock protein HSP 90-beta
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Heat shock protein HSP 90-beta matters

As of 2026-09-13

Heat shock protein HSP 90-beta is reviewed as Heat shock protein HSP 90-beta (UniProt P08238); the current evidence base includes 0 approved drugs, 1055 compounds, and 473 assays, with lead potency reaching pChEMBL 10.2.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 0 approved drugs, 1055 compounds, and 473 assays for this target. The dominant activity type is IC50. CHEMBL252164 is the current potency anchor at pChEMBL 10.2.

Use CHEMBL252164 as the tractability anchor when discussing potency (pChEMBL 10.2).

Activity source · ChEMBL 36 via Core Engine
pChEMBL 10.2
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Heat shock protein HSP 90-beta matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P08238, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1055
Total Compounds
473
Total Assays
0
Approved Drugs
IC50: 709.0, KI: 151.0, EC50: 35.0, KD: 199.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL252164
 10.2 Ki Clinical
No preferred name
CHEMBL1917878
 9.5 Kd —
No preferred name
CHEMBL3752910
 9.3 Kd —
No preferred name
CHEMBL3309997
 9.0 Ki —
No preferred name
CHEMBL560895
 9.0 Ki —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T21:24:45Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4303