Serine/threonine-protein kinase PAK 6 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q9NQU5. Use UniProt Q9NQU5 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NQU5 as the stable identity anchor, then attach disease evidence before program review.
Serine/threonine-protein kinase PAK 6
Review this target as Serine/threonine-protein kinase PAK 6, mapped to UniProt Q9NQU5. Sequence length is 681 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase PAK 6 as ChEMBL target CHEMBL4311, mapped to UniProt Q9NQU5. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Serine/threonine-protein kinase PAK 6 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NQU5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase PAK 6 |
| UniProt Accession | Q9NQU5 |
| Component Type | Protein |
| Sequence Length | 681 aa |
Serine/threonine-protein kinase PAK 6
Review this target as Serine/threonine-protein kinase PAK 6, mapped to UniProt Q9NQU5. Sequence length is 681 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.4 | Kd | 0.4 | Preclinical |
| CHEMBL3128043 | 8.52 | Kd | 3.0 | Preclinical |
| CHEMBL574737 | 8.4 | Kd | 4.0 | Clinical |
| CHEMBL494089 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL603469 | 8.0 | Kd | 9.9 | Clinical |
| CHEMBL3128043 | 7.77 | IC50 | 17.1 | Preclinical |
| CHEMBL3545137 | 7.72 | Kd | 19.0 | Preclinical |
| CHEMBL494089 | 7.68 | Kd | 21.0 | Preclinical |
| CHEMBL4465866 | 7.66 | Kd | 22.0 | Preclinical |
| CHEMBL4576489 | 7.6 | Kd | 25.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 232 | 24 | 6.7 |
| assay format | 31 | 3 | 7.5 |
| cell-based format | 10 | 0 | — |
| subcellular format | 1 | 5 | 7.6 |