Review anchor
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
CHEMBL4438
SINGLE PROTEIN
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein phosphatase PP1-gamma catalytic subunit as ChEMBL target CHEMBL4438, mapped to UniProt P36873. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4438
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P36873
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Serine/threonine-protein phosphatase PP1-gamma catalytic subunit matters
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is reviewed as Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (UniProt P36873); the current evidence base includes 1 approved drug, 32 compounds, and 34 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit Sequence length is 323 aa.
Review this target as Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, mapped to UniProt P36873. Sequence length is 323 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P36873
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 32 compounds, and 34 assays for this target. The dominant activity type is IC50. CHEMBL444092 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL444092 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Serine/threonine-protein phosphatase PP1-gamma catalytic subunit matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P36873, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
32
Total Compounds
34
Total Assays
1
Approved Drugs
IC50: 50.0, KI: 10.0, KD: 1.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL444092
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL430266
|
9.8 | IC50 | — |
|
|
No preferred name
CHEMBL1366322
|
8.8 | IC50 | — |
|
|
No preferred name
CHEMBL408120
|
8.5 | Ki | — |
|
|
No preferred name
CHEMBL406220
|
8.3 | Ki | — |
Source Header