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Evidence Snapshot

Tyrosine-protein kinase Fgr

CHEMBL4454 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:18Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4454
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tyrosine-protein kinase Fgr as ChEMBL target CHEMBL4454, mapped to UniProt P09769. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tyrosine-protein kinase Fgr
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4454
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09769
Tyrosine-protein kinase Fgr
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Tyrosine-protein kinase Fgr matters

As of 2026-09-14

Tyrosine-protein kinase Fgr is reviewed as Tyrosine-protein kinase Fgr (UniProt P09769); the current evidence base includes 23 approved drugs, 1154 compounds, and 347 assays, with lead potency reaching pChEMBL 9.5.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 23 approved drugs, 1154 compounds, and 347 assays for this target. The dominant activity type is KD. CHEMBL249097 is the current potency anchor at pChEMBL 9.5.

Use CHEMBL249097 as the tractability anchor when discussing potency (pChEMBL 9.5).

Activity source · ChEMBL 36 via Core Engine
23 approved pChEMBL 9.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Tyrosine-protein kinase Fgr matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P09769, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1154
Total Compounds
347
Total Assays
23
Approved Drugs
IC50: 129.0, KI: 2.0, EC50: 1.0, KD: 222.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL249097
 9.5 Kd —
No preferred name
CHEMBL3647967
 9.4 IC50 —
No preferred name
CHEMBL5416410
 9.3 Kd Approved
No preferred name
CHEMBL388978
 9.2 IC50 —
No preferred name
CHEMBL364623
 9.1 IC50 —

Approved Drugs

Structure Compound First Approval
FEDRATINIB
CHEMBL1287853
 2019
ZANUBRUTINIB
CHEMBL3936761
 2019
BRIGATINIB
CHEMBL3545311
 2017
MIDOSTAURIN
CHEMBL608533
 2017
NINTEDANIB
CHEMBL502835
 2014
IBRUTINIB
CHEMBL1873475
 2013
BOSUTINIB
CHEMBL288441
 2012
PONATINIB
CHEMBL1171837
 2012
AXITINIB
CHEMBL1289926
 2012
VANDETANIB
CHEMBL24828
 2011
CRIZOTINIB
CHEMBL601719
 2011
NILOTINIB
CHEMBL255863
 2007
DASATINIB
CHEMBL5416410
 2006
SUNITINIB
CHEMBL535
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:18Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4454