Neuronal acetylcholine receptor subunit alpha-4 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt O70174. Use UniProt O70174 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O70174 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit alpha-4
Review this target as Neuronal acetylcholine receptor subunit alpha-4, mapped to UniProt O70174. Sequence length is 629 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-4 as ChEMBL target CHEMBL4457, mapped to UniProt O70174. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor subunit alpha-4 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O70174 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit alpha-4 |
| UniProt Accession | O70174 |
| Component Type | Protein |
| Sequence Length | 629 aa |
Neuronal acetylcholine receptor subunit alpha-4
Review this target as Neuronal acetylcholine receptor subunit alpha-4, mapped to UniProt O70174. Sequence length is 629 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL6623 | 10.43 | IC50 | 0.037 | Preclinical |
| CHEMBL72675 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL71046 | 8.36 | IC50 | 4.4 | Preclinical |
| CHEMBL3 | 8.15 | IC50 | 7.0 | Approved |
| CHEMBL309804 | 8.09 | IC50 | 8.2 | Preclinical |
| CHEMBL2270633 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL451432 | 6.07 | IC50 | 860.0 | Preclinical |
| CHEMBL406819 | 5.58 | IC50 | 2600.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 8 | 7.8 |