Review anchor
Neuronal acetylcholine receptor subunit alpha-4
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
Evidence Snapshot
Neuronal acetylcholine receptor subunit alpha-4
CHEMBL4457
SINGLE PROTEIN
Mus musculus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-4 as ChEMBL target CHEMBL4457, mapped to UniProt O70174. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4457
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O70174
Neuronal acetylcholine receptor subunit alpha-4
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Neuronal acetylcholine receptor subunit alpha-4 matters
Neuronal acetylcholine receptor subunit alpha-4 is reviewed as Neuronal acetylcholine receptor subunit alpha-4 (UniProt O70174); the current evidence base includes 1 approved drug, 8 compounds, and 1 assay, with lead potency reaching pChEMBL 10.4.
Protein context
Neuronal acetylcholine receptor subunit alpha-4
Neuronal acetylcholine receptor subunit alpha-4 Sequence length is 629 aa.
Review this target as Neuronal acetylcholine receptor subunit alpha-4, mapped to UniProt O70174. Sequence length is 629 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt O70174
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 8 compounds, and 1 assay for this target. The dominant activity type is IC50. CHEMBL6623 is the current potency anchor at pChEMBL 10.4.
Use CHEMBL6623 as the tractability anchor when discussing potency (pChEMBL 10.4).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 10.4
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Neuronal acetylcholine receptor subunit alpha-4 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt O70174, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
8
Total Compounds
1
Total Assays
1
Approved Drugs
IC50: 8.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL6623
|
10.4 | IC50 | — |
|
|
No preferred name
CHEMBL72675
|
8.8 | IC50 | — |
|
|
No preferred name
CHEMBL71046
|
8.4 | IC50 | — |
|
|
No preferred name
CHEMBL3
|
8.2 | IC50 | Approved |
|
|
No preferred name
CHEMBL309804
|
8.1 | IC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
NICOTINE
CHEMBL3
|
1984 |
Source Header