Use UniProt P21183 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL4523198 Target Snapshot
Interleukin-5 receptor subunit alpha · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P21183. Use UniProt P21183 as the stable identity anchor, then attach disease evidence before program review.
Interleukin-5 receptor subunit alpha
Review this target as Interleukin-5 receptor subunit alpha, mapped to UniProt P21183. Sequence length is 415 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Interleukin-5 receptor subunit alpha as ChEMBL target CHEMBL4523198, mapped to UniProt P21183. Disease framing currently uses the Open Targets-ready proxy contract.
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Open Review-ready CardBasic Information
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| Preferred Name | Interleukin-5 receptor subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P21183 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Interleukin-5 receptor subunit alpha |
| UniProt Accession | P21183 |
| Component Type | Protein |
| Sequence Length | 415 aa |
Interleukin-5 receptor subunit alpha
How to read this target
Review this target as Interleukin-5 receptor subunit alpha, mapped to UniProt P21183. Sequence length is 415 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4463994 | 5.46 | IC50 | 3500.0 | Preclinical |
| CHEMBL4586328 | 5.3 | IC50 | 5000.0 | Preclinical |
| CHEMBL4581146 | 5.12 | IC50 | 7500.0 | Preclinical |
| CHEMBL486626 | 4.97 | IC50 | 10600.0 | Preclinical |
| CHEMBL4562876 | 4.92 | IC50 | 12000.0 | Preclinical |
| CHEMBL4445471 | 4.89 | IC50 | 13000.0 | Preclinical |
| CHEMBL4438982 | 4.72 | IC50 | 19000.0 | Preclinical |
| CHEMBL4459407 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL4475617 | 4.7 | IC50 | 20000.0 | Preclinical |
| CHEMBL4534125 | 4.7 | IC50 | 20000.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 3 assays, 17 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 17 | 4.8 |