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Target Snapshot

CHEMBL4523198 Target Snapshot

Interleukin-5 receptor subunit alpha · SINGLE PROTEIN · Mus musculus

27Compounds
3Assays
1Approved Drugs
27.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P21183. Use UniProt P21183 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P21183 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Interleukin-5 receptor subunit alpha as ChEMBL target CHEMBL4523198, mapped to UniProt P21183. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Interleukin-5 receptor subunit alpha
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4523198
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P21183
Interleukin-5 receptor subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Interleukin-5 receptor subunit alpha is the right protein anchor across sources, using UniProt P21183 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelInterleukin-5 receptor subunit alpha
UniProt AccessionP21183
Component TypeProtein
Sequence Length415 aa

Interleukin-5 receptor subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Interleukin-5 receptor subunit alpha, mapped to UniProt P21183. Sequence length is 415 aa.

Mapped IDP21183
Review nameInterleukin-5 receptor subunit alpha
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5027.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4463994 5.46 IC50 3500.0 Preclinical
CHEMBL4586328 5.3 IC50 5000.0 Preclinical
CHEMBL4581146 5.12 IC50 7500.0 Preclinical
CHEMBL486626 4.97 IC50 10600.0 Preclinical
CHEMBL4562876 4.92 IC50 12000.0 Preclinical
CHEMBL4445471 4.89 IC50 13000.0 Preclinical
CHEMBL4438982 4.72 IC50 19000.0 Preclinical
CHEMBL4459407 4.7 IC50 20000.0 Preclinical
CHEMBL4475617 4.7 IC50 20000.0 Preclinical
CHEMBL4534125 4.7 IC50 20000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
17
Tested Compounds
1
Assay Types
Binding — 3 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 17 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine