tRNA (guanine-N(1)-)-methyltransferase · SINGLE PROTEIN · Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1)
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As of 2026-09-14Protein identity stays anchored to UniProt Q9HXQ1. Use UniProt Q9HXQ1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9HXQ1 as the stable identity anchor, then attach disease evidence before program review.
tRNA (guanine-N(1)-)-methyltransferase
Review this target as tRNA (guanine-N(1)-)-methyltransferase, mapped to UniProt Q9HXQ1. Sequence length is 252 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats tRNA (guanine-N(1)-)-methyltransferase as ChEMBL target CHEMBL4523932, mapped to UniProt Q9HXQ1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | tRNA (guanine-N(1)-)-methyltransferase |
| Target Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| UniProt | Q9HXQ1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | tRNA (guanine-N(1)-)-methyltransferase |
| UniProt Accession | Q9HXQ1 |
| Component Type | Protein |
| Sequence Length | 252 aa |
tRNA (guanine-N(1)-)-methyltransferase
Review this target as tRNA (guanine-N(1)-)-methyltransferase, mapped to UniProt Q9HXQ1. Sequence length is 252 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4517402 | 8.8 | Kd | 1.6 | Preclinical |
| CHEMBL4517402 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL4513615 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL4447065 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL4463176 | 7.07 | IC50 | 85.0 | Preclinical |
| CHEMBL2431997 | 7.04 | Kd | 91.0 | Preclinical |
| CHEMBL4543513 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4555967 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4580116 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL4437560 | 6.85 | IC50 | 140.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 27 | 6.5 |
| assay format | 2 | 2 | 6.6 |