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Evidence Snapshot

Activated CDC42 kinase 1

CHEMBL4599 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4599
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Activated CDC42 kinase 1 as ChEMBL target CHEMBL4599, mapped to UniProt Q07912. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Activated CDC42 kinase 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4599
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q07912
Activated CDC42 kinase 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Activated CDC42 kinase 1 matters

As of 2026-09-14

Activated CDC42 kinase 1 is reviewed as Activated CDC42 kinase 1 (UniProt Q07912); the current evidence base includes 30 approved drugs, 2139 compounds, and 344 assays, with lead potency reaching pChEMBL 9.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 30 approved drugs, 2139 compounds, and 344 assays for this target. The dominant activity type is IC50. CHEMBL2087874 is the current potency anchor at pChEMBL 9.7.

Use CHEMBL2087874 as the tractability anchor when discussing potency (pChEMBL 9.7).

Activity source · ChEMBL 36 via Core Engine
30 approved pChEMBL 9.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Activated CDC42 kinase 1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q07912, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2139
Total Compounds
344
Total Assays
30
Approved Drugs
IC50: 741.0, KI: 444.0, KD: 387.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL2087874
 9.7 Ki —
No preferred name
CHEMBL5400397
 9.7 IC50 —
No preferred name
CHEMBL2087873
 9.5 Ki —
No preferred name
CHEMBL2087875
 9.5 Ki —
No preferred name
CHEMBL5408748
 9.5 IC50 —

Approved Drugs

Structure Compound First Approval
ENTRECTINIB
CHEMBL1983268
 2019
FEDRATINIB
CHEMBL1287853
 2019
LORLATINIB
CHEMBL3286830
 2018
LAROTRECTINIB
CHEMBL3889654
 2018
MIDOSTAURIN
CHEMBL608533
 2017
NERATINIB
CHEMBL180022
 2017
OSIMERTINIB
CHEMBL3353410
 2015
CERITINIB
CHEMBL2403108
 2014
BOSUTINIB
CHEMBL288441
 2012
VEMURAFENIB
CHEMBL1229517
 2011
CRIZOTINIB
CHEMBL601719
 2011
DASATINIB
CHEMBL5416410
 2006
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-14T03:22:14Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4599