Histamine H2 receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P25102. Use UniProt P25102 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P25102 as the stable identity anchor, then attach disease evidence before program review.
Histamine H2 receptor
Review this target as Histamine H2 receptor, mapped to UniProt P25102. Sequence length is 358 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H2 receptor as ChEMBL target CHEMBL4654, mapped to UniProt P25102. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histamine H2 receptor is the right protein anchor across sources, using UniProt P25102 as the stable mapping.
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| Preferred Name | Histamine H2 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P25102 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H2 receptor |
| UniProt Accession | P25102 |
| Component Type | Protein |
| Sequence Length | 358 aa |
Histamine H2 receptor
Review this target as Histamine H2 receptor, mapped to UniProt P25102. Sequence length is 358 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL285556 | 7.8 | Kd | 15.85 | Preclinical |
| CHEMBL284374 | 7.3 | Kd | 50.12 | Preclinical |
| CHEMBL33398 | 6.8 | Kd | 158.49 | Preclinical |
| CHEMBL33698 | 6.6 | Kd | 251.19 | Preclinical |
| CHEMBL265987 | 6.6 | Kd | 251.19 | Preclinical |
| CHEMBL30 | 6.6 | Kd | 251.19 | Approved |
| CHEMBL285719 | 6.5 | Kd | 316.23 | Preclinical |
| CHEMBL406844 | 6.5 | Kd | 316.23 | Preclinical |
| CHEMBL282645 | 6.5 | Kd | 316.23 | Preclinical |
| CHEMBL30917 | 6.4 | Kd | 398.11 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 23 | 4.3 |
| cell-based format | 2 | 3 | 5.0 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 10 | 0 | — |
| assay format | 2 | 39 | 6.2 |