Histamine H1 receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P31390. Use UniProt P31390 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31390 as the stable identity anchor, then attach disease evidence before program review.
Histamine H1 receptor
Review this target as Histamine H1 receptor, mapped to UniProt P31390. Sequence length is 486 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histamine H1 receptor as ChEMBL target CHEMBL4701, mapped to UniProt P31390. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histamine H1 receptor is the right protein anchor across sources, using UniProt P31390 as the stable mapping.
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| Preferred Name | Histamine H1 receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P31390 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histamine H1 receptor |
| UniProt Accession | P31390 |
| Component Type | Protein |
| Sequence Length | 486 aa |
Histamine H1 receptor
Review this target as Histamine H1 receptor, mapped to UniProt P31390. Sequence length is 486 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL629 | 10.7 | IC50 | 0.02 | Approved |
| CHEMBL445 | 10.3 | IC50 | 0.05 | Approved |
| CHEMBL11 | 10.22 | IC50 | 0.06 | Approved |
| CHEMBL415 | 9.7 | IC50 | 0.2 | Approved |
| CHEMBL715 | 9.52 | Ki | 0.3 | Approved |
| CHEMBL414174 | 9.3 | Ki | 0.5012 | Preclinical |
| CHEMBL72 | 9.1 | IC50 | 0.8 | Approved |
| CHEMBL643 | 9.0 | Ki | 1.0 | Approved |
| CHEMBL908 | 8.97 | IC50 | 1.072 | Approved |
| CHEMBL46683 | 8.91 | Ki | 1.22 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 14 | 22 | 7.8 |
| tissue-based format | 13 | 24 | 7.6 |
| assay format | 9 | 38 | 7.2 |
| cell membrane format | 8 | 60 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 24 | 11 | 7.2 |