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Evidence Snapshot

Histamine H1 receptor

CHEMBL4701 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4701
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Histamine H1 receptor as ChEMBL target CHEMBL4701, mapped to UniProt P31390. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Histamine H1 receptor
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL4701
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P31390
Histamine H1 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Histamine H1 receptor matters

As of 2026-09-13

Histamine H1 receptor is reviewed as Histamine H1 receptor (UniProt P31390); the current evidence base includes 29 approved drugs, 208 compounds, and 68 assays, with lead potency reaching pChEMBL 10.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 29 approved drugs, 208 compounds, and 68 assays for this target. The dominant activity type is KI. CHEMBL629 is the current potency anchor at pChEMBL 10.7.

Use CHEMBL629 as the tractability anchor when discussing potency (pChEMBL 10.7).

Activity source · ChEMBL 36 via Core Engine
29 approved pChEMBL 10.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Histamine H1 receptor matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P31390, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

208
Total Compounds
68
Total Assays
29
Approved Drugs
IC50: 61.0, KI: 149.0, EC50: 15.0, KD: 9.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL629
 10.7 IC50 Approved
No preferred name
CHEMBL445
 10.3 IC50 Approved
No preferred name
CHEMBL11
 10.2 IC50 Approved
No preferred name
CHEMBL415
 9.7 IC50 Approved
No preferred name
CHEMBL715
 9.5 Ki Approved

Approved Drugs

Structure Compound First Approval
ZIPRASIDONE
CHEMBL708
 2001
QUETIAPINE
CHEMBL716
 1997
OLANZAPINE
CHEMBL715
 1996
LORATADINE
CHEMBL998
 1993
RISPERIDONE
CHEMBL85
 1993
CLOMIPRAMINE
CHEMBL415
 1989
CLOZAPINE
CHEMBL42
 1989
AZATADINE
CHEMBL946
 1977
LOXAPINE
CHEMBL831
 1975
PYRILAMINE
CHEMBL511
 1973
CHLORPROTHIXENE
CHEMBL908
 1967
HALOPERIDOL
CHEMBL54
 1967
DESIPRAMINE
CHEMBL72
 1964
NORTRIPTYLINE
CHEMBL445
 1964
THIORIDAZINE
CHEMBL479
 1962
AMITRIPTYLINE
CHEMBL629
 1961
IMIPRAMINE
CHEMBL11
 1959
ORPHENADRINE
CHEMBL900
 1957
PROMETHAZINE
CHEMBL643
 1951
CHLORPHENIRAMINE
CHEMBL505
 1950
HISTAMINE
CHEMBL90
 1939
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:31Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL4701