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Target Snapshot

CHEMBL4739852 Target Snapshot

Forkhead box protein M1 · SINGLE PROTEIN · Homo sapiens

25Compounds
43Assays
1Approved Drugs
28.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q08050. Use UniProt Q08050 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q08050 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Forkhead box protein M1 as ChEMBL target CHEMBL4739852, mapped to UniProt Q08050. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Forkhead box protein M1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4739852
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q08050
Forkhead box protein M1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Forkhead box protein M1 is the right protein anchor across sources, using UniProt Q08050 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelForkhead box protein M1
UniProt AccessionQ08050
Component TypeProtein
Sequence Length763 aa

Forkhead box protein M1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Forkhead box protein M1, mapped to UniProt Q08050. Sequence length is 763 aa.

Mapped IDQ08050
Review nameForkhead box protein M1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5013.0
KI13.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5089001 7.96 Ki 11.0 Preclinical
CHEMBL5089499 7.85 Ki 14.0 Preclinical
CHEMBL4740210 7.67 Ki 21.46 Preclinical
CHEMBL5075226 7.4 Ki 40.0 Preclinical
CHEMBL5075356 7.29 Ki 51.0 Preclinical
CHEMBL408 7.28 Ki 51.97 Approved
CHEMBL5081655 7.19 Ki 65.0 Preclinical
CHEMBL5076752 7.12 Ki 76.0 Preclinical
CHEMBL5089867 7.0 Ki 100.0 Preclinical
CHEMBL5092745 6.89 Ki 130.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
5
6.5
6
7.0
3
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TROGLITAZONE
CHEMBL408
Approved 1997
Assay Landscape

Assay Landscape

43
Total Assays
25
Tested Compounds
1
Assay Types
Binding — 43 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 39 0
single protein format 3 23 5.8
assay format 1 2 6.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine