Compound Detail
CHEMBL4740210
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Basic Information
| ChEMBL ID | CHEMBL4740210 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QWMCMTYHOHEFMD-SXGWCWSVSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
4.62
ALogP
5
HBA
1
HBD
64.6
PSA (Ų)
0.73
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.3
Ki 1 meas. best 7.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Forkhead box protein M1 CHEMBL4739852 | Ki | 7.67 | 7.67 | 21.5 | 1 |
| Forkhead box protein M1 CHEMBL4739852 | IC50 | 4.3 | 4.3 | 50540.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Forkhead box protein M1 | Ki | = | 21.46 | nM | 7.67 | Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escheric... | 33069434 |
| Forkhead box protein M1 | IC50 | = | 50540.0 | nM | 4.3 | Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escheric... | 33069434 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33069434 | 10.1016/j.ejmech.2020.112902 | Forkhead box protein M1 | 6 |
| 33069434 | 10.1016/j.ejmech.2020.112902 | Unchecked | 2 |
| 33069434 | 10.1016/j.ejmech.2020.112902 | MDA-MB-231 | 2 |
Data from ChEMBL 36 via Core Engine