Assay Detail
Binding
CHEMBL4733556
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Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex preincubated for 1.5 hrs followed by DNA addition measured after 20 mins by EMSA
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SP1-independent inhibition of FOXM1 by modified thiazolidinediones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.48 | 7.67 |
| IC50 | 2 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4740210 | — | — | 2 | 7.67 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 2 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4740210 | — | Ki | = | 21.46 | nM | 7.67 |
| CHEMBL408 | TROGLITAZONE | Ki | = | 51.97 | nM | 7.28 |
| CHEMBL4740210 | — | IC50 | = | 50540.0 | nM | 4.30 |
| CHEMBL408 | TROGLITAZONE | IC50 | = | 122400.0 | nM | - |