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Target Snapshot

CHEMBL4754 Target Snapshot

Glutamyl-tRNA(Gln) amidotransferase subunit C · SINGLE PROTEIN · Streptococcus pyogenes serotype M1

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21Compounds
2Assays
0Approved Drugs
42.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P68890. Use UniProt P68890 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P68890 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutamyl-tRNA(Gln) amidotransferase subunit C as ChEMBL target CHEMBL4754, mapped to UniProt P68890. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutamyl-tRNA(Gln) amidotransferase subunit C
SINGLE PROTEIN · Streptococcus pyogenes serotype M1
As of 2026-09-14
ChEMBL target ID
CHEMBL4754
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P68890
Glutamyl-tRNA(Gln) amidotransferase subunit C
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutamyl-tRNA(Gln) amidotransferase subunit C is the right protein anchor across sources, using UniProt P68890 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameGlutamyl-tRNA(Gln) amidotransferase subunit C
Target TypeSINGLE PROTEIN
OrganismStreptococcus pyogenes serotype M1
UniProtP68890
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutamyl-tRNA(Gln) amidotransferase subunit C
UniProt AccessionP68890
Component TypeProtein
Sequence Length100 aa

Glutamyl-tRNA(Gln) amidotransferase subunit C

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Glutamyl-tRNA(Gln) amidotransferase subunit C, mapped to UniProt P68890. Sequence length is 100 aa.

Mapped IDP68890
Review nameGlutamyl-tRNA(Gln) amidotransferase subunit C
OrganismStreptococcus pyogenes serotype M1
Assay Mix

Activity Type Distribution

IC5042.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL85937 7.3 IC50 50.0 Preclinical
CHEMBL85646 7.16 IC50 70.0 Preclinical
CHEMBL87796 7.0 IC50 100.0 Preclinical
CHEMBL83517 5.96 IC50 1100.0 Preclinical
CHEMBL83018 5.33 IC50 4700.0 Preclinical
CHEMBL86297 5.19 IC50 6500.0 Preclinical
CHEMBL85696 5.0 IC50 10000.0 Preclinical
CHEMBL432771 4.7 IC50 20000.0 Preclinical
CHEMBL87299 4.7 IC50 20000.0 Preclinical
CHEMBL85709 4.46 IC50 35000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
4
5.5
0
6.0
0
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
10
Tested Compounds
1
Assay Types
Binding — 2 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 10 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine