Compound Detail
CHEMBL87299
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CC1(C)C2CC[C@]3(C)OB(CC[C@H](N)C(=O)NS(=O)(=O)c4ccccc4)O[C@]13C2
Basic Information
| ChEMBL ID | CHEMBL87299 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | USGIIRFFLYDFSN-MESKKRNCSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
420.3
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamyl-tRNA(Gln) amidotransferase subunit C CHEMBL4754 | IC50 | 4.7 | 4.55 | 20000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamyl-tRNA(Gln) amidotransferase subunit C | IC50 | = | 20000.0 | nM | 4.7 | In vitro inhibitory concentration against transferase activity of bacterial Glu-... | 11549469 |
| Glutamyl-tRNA(Gln) amidotransferase subunit C | IC50 | = | 40000.0 | nM | 4.4 | In vitro inhibitory concentration against Glutaminase activity of bacterial Glu-... | 11549469 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11549469 | 10.1016/s0960-894x(01)00499-1 | Glutamyl-tRNA(Gln) amidotransferase subunit C | 2 |
Data from ChEMBL 36 via Core Engine