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Assay Detail

CHEMBL684767

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibitory concentration against transferase activity of bacterial Glu-tRNA-Gln aminotransferase (Glu-AdT)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Streptococcus pyogenes
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glutamyl-tRNA(Gln) amidotransferase subunit C (CHEMBL4754)
Type SINGLE PROTEIN
Organism Streptococcus pyogenes serotype M1

Publication

Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase.
Decicco CP, Nelson DJ, Luo Y, Shen L, Horiuchi KY, Amsler KM, Foster LA, Spitz SM, Merrill JJ, Sizemore CF, Rogers KC, Copeland RA, Harpel MR.
Bioorg Med Chem Lett (2001) 11 : 2561 -2564
PubMed 11549469 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.68 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85937 1 7.30
CHEMBL85646 1 7.16
CHEMBL87796 1 7.00
CHEMBL83517 1 5.96
CHEMBL83018 1 5.33
CHEMBL86297 1 5.19
CHEMBL85696 1 5.00
CHEMBL87299 1 4.70
CHEMBL432771 1 4.70
CHEMBL85709 1 4.46
CHEMBL315075 1 -
CHEMBL82811 1 -
CHEMBL419857 1 -
CHEMBL315413 1 -
CHEMBL315537 1 -
CHEMBL313581 1 -
CHEMBL313669 1 -
CHEMBL85819 1 -
CHEMBL316377 1 -
CHEMBL314857 1 -
CHEMBL86135 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85937 IC50 = 50.0 nM 7.30
CHEMBL85646 IC50 = 70.0 nM 7.16
CHEMBL87796 IC50 = 100.0 nM 7.00
CHEMBL83517 IC50 = 1100.0 nM 5.96
CHEMBL83018 IC50 = 4700.0 nM 5.33
CHEMBL86297 IC50 = 6500.0 nM 5.19
CHEMBL85696 IC50 = 10000.0 nM 5.00
CHEMBL87299 IC50 = 20000.0 nM 4.70
CHEMBL432771 IC50 = 20000.0 nM 4.70
CHEMBL85709 IC50 = 35000.0 nM 4.46
CHEMBL315075 IC50 > 20000.0 nM -
CHEMBL82811 IC50 > 20000.0 nM -
CHEMBL419857 IC50 - nM -
CHEMBL315413 IC50 - nM -
CHEMBL315537 IC50 > 20000.0 nM -
CHEMBL313581 IC50 > 20000.0 nM -
CHEMBL313669 IC50 > 20000.0 nM -
CHEMBL85819 IC50 > 20000.0 nM -
CHEMBL316377 IC50 > 20000.0 nM -
CHEMBL314857 IC50 > 20000.0 nM -
CHEMBL86135 IC50 > 20000.0 nM -